CONTROL-T PUBLICATIONS

Micro-RNA networks in T-cell prolymphocytic leukemia reflect T-cell activation and shape DNA damage response and survival pathways.
Till Braun, Markus Glass, Linus Wahnschaffe, Moritz Otte, Petra Mayer, Marek Franitza, Janine Altmüller, Michael Hallek, Stefan Hüttelmaier, Alexandra Schrader, Marco Herling,
Haematologica Nov 19, 2020 doi: 10.3324/haematol.2020.267500.

Non-canonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling
Sebastian Oberbeck, Alexandra Schrader, Kathrin Warner, Dennis Jungherz, Giuliano Crispatzu, Jana von Jan, Markus Chmielewski, Aleksandr Ianevski, Hans H. Diebner, Petra Mayer, Aichatou Kondo Ados, Linus Wahnschaffe, Till Braun, Tony A. Müller, Prerana Wagle, Alyssa Bouska, Tom Neumann, Sabine Pützer, Lesley Varghese, Natali Pflug, Martin Thelen, Jennifer Makalowski, Nicole Riet, Hedwig Julia Maria Göx, Gunter Rappl, Janine Altmüller, Michaela Kotrova, Thorsten Persigehl, Georg Hopfinger, Martin L Hansmann, Hans Schlößer, Stephan Stilgenbauer, Jan Dürig, Dimitrios Mougiakakos, Michael von Bergwelt-Baildon, Ingo Roeder, Sylvia Hartmann, Michael Hallek, Richard H Moriggl, Monika Brüggemann, Tero Aittokallio, Javeed Iqbal, Sebastian Newrzela, Hinrich Abken, Marco Herling
Blood 2020, Vol. 136 (24), 2786-2802. doi: doi: 10.1182/blood.2019003348

Identifying Genetic Lesions in Ocular Adnexal Extranodal Marginal Zone Lymphomas of the MALT Subtype by Whole Genome, Whole Exome and Targeted Sequencing.
Johansson, Patricia; Klein-Hitpass, Ludger; Budeus, Bettina; Kuhn, Matthias; Lauber, Chris; Seifert, Michael; Roeder, Ingo; Pförtner, Roman; Stuschke, Martin; Dührsen, Ulrich; Eckstein, Anja; Dürig, Jan; Küppers, Ralf.
Cancers 2020, Vol. 12, 986. doi: 10.3390/cancers12040986

Advances and Perspectives in the Treatment of T-PLL.
Till Braun, Jana von Jan, Linus Wahnschaffe, Marco Herling
Current Hematologic Malignancy Reports, 2020. doi: 10.1007/s11899-020-00566-5.

STAT3 Mutation Is Associated with STAT3 Activation in CD30 + ALK − ALCL.
Emma I. Andersson, Oscar Brück, Till Braun, Susanna Mannisto, Leena Saikko, Sonja Lagström, Pekka Ellonen, Sirpa Leppä, Marco Herling, Panu E. Kovanen, Satu Mustjoki:
Cancers, 2020, Vol. 12, 702. doi: 10.3390/cancers12030702

Reinstated p53 response and high anti-T-cell leukemia activity by the novel alkylating deacetylase inhibitor tinostamustine.
S. Pützer, L. Varghese. J. von Jan, T. Braun, A. K. Giri, P. Mayer, N. Riet, S. Timonen, S. Oberbeck, H. Kuusanmäki, S. Mustjoki, M.-H. Stern, T. Aittokallio, S. Newrzela, A. Schrader, M. Herling.
Leukemia, 2020. doi: 10.1038/s41375-020-0772-6

Next-Generation Amplicon TRB Locus Sequencing Can Overcome Limitations of Flow-Cytometric Vβ Expression Analysis and Confirms Clonality in all T-Cell Prolymphocytic Leukemia Cases
Michaela Kotrova, Michaela Novakova, Sebastian Oberbeck, Petra Mayer, Alexandra Schrader, Henrik Knecht, Ondrej Hrusak, Marco Herling, Monika Brüggemann
Cytometry Part A 2018. 10.1002/cyto.a.23604

Reconstruction of rearranged T‐cell receptor loci by whole genome and transcriptome sequencing gives insights into the initial steps of T‐cell prolymphocytic leukemia.
Paurnima Patil, Agata Cieslak, Stephan H. Bernhart, Umut H. Toprak, Rabea Wagener, Cristina López, Laura Wiehle, Susanne Bens, Janine Altmüller, Marek Franitza, Ingrid Scholz, Sandrine Jayne, Matthew J. Ahearne, Annika Scheffold, Billy M. C. Jebaraj, Christof Schneider, Dolors Costa, Till Braun, Alexandra Schrader, Elias Campo, Martin J. S. Dyer, Peter Nürnberg, Jan Dürig, Patricia Johansson, Sebastian Böttcher, Matthias Schlesner, Marco Herling, Stephan Stilgenbauer, Elizabeth Macintyre, Reiner Siebert.
Genes Chromosomes Cancer, 2019, 1-7. doi: 10.1002/gcc.22821

Migration Properties Distinguish Tumor Cells of Classical Hodgkin Lymphoma from Anaplastic Large Cell Lymphoma Cells.
Goncharova, O.; Flinner, N.; Bein, J.; Döring, C.; Donnadieu, E.; Rikirsch, S.; Herling, M.; Küppers, R.; Hansmann, M.-L.; Hartmann, S.
Cancers 2019, 11, 1484. doi: 10.3390/cancers11101484

The dawn of a new era in treating T-PLL.
Alexandra Schrader, Till Braun and Marco Herling.
Oncotarget, 2019, Vol. 10, (No. 6), pp: 626-628. doi:10.18632/oncotarget.26595

JUNB, DUSP2, SGK1, SOCS1 and CREBBP are frequently mutated in T-cell/histiocyte-rich large B-cell lymphoma.
Bianca Schuhmacher, Julia Bein, Tobias Rausch, Vladimir Benes, Thomas Tousseyn, Martine Vornanen, Maurilio Ponzoni, Lorenz Thurner, Randy Gascoyne, Christian Steidl, Ralf Küppers, Martin-Leo Hansmann, and Sylvia Hartmann.
Haematologica, 2018, Vol 104(2), pp. 330-337. doi:10.3324/haematol.2018.203224

CD30 expression in neoplastic T cells of follicular T cell lymphoma is a helpful diagnostic tool in the differential diagnosis of Hodgkin lymphoma.
Sylvia Hartmann, Olga Goncharova, Anna Portyanko, Elena Sabattini, Jörn Meinel, Ralf Küppers, Claudio Agostinelli, Stefano Aldo Pileri, Martin-Leo Hansmann.
Modern Pathology, Aug. 23, 2018. 10.1038/s41379-018-0108-5

Metabolism is the Tie: The Bertalanffy-type Cancer Growth Model as Common Denominator of Various Modelling Approaches.
Diebner HH, Zerjatke T, Griehl M, Roeder I.
BioSystems 167:1-23, Mar 29, 2018doi:10.1016/j.biosystems.2018.03.004

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.
A. Schrader, G. Crispatzu, S. Oberbeck, P. Mayer, S. Pützer, J. von Jan, E. Vasyutina, K. Warner, N. Weit, N. Pflug, T. Braun, E.I. Andersson,B. Yadav, A. Riabinska, B. Maurer, M.S. Ventura Ferreira, F. Beier, J. Altmüller, M. Lanasa, C.D. Herling , T. Haferlach, S. Stilgenbauer, G. Hopfinger, M. Peifer, T.H. Brümmendorf, P. Nürnberg, K.S.J. Elenitoba-Johnson, S. Zha, M. Hallek, R. Moriggl, H.C. Reinhardt, M.-H. Stern, S. Mustjoki, S. Newrzela, P. Frommolt, M. Herling.
Nature Communications, 9, Article number: 697, 2018. doi:10.1038/s41467-017-02688-6

SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia.
Johansson P, Klein-Hitpass L, Choidas A, Habenberger P, Mahboubi B, Kim B, Bergmann A, Scholtysik R, Brauser M, Lollies A, Siebert R, Zenz T, Dührsen U, Küppers R, Dürig J.
Blood Cancer J., 8, Article number: 11, 2018. doi:10.1038/s41408-017-0036-5

TET2 mutations in B cells of patients affected by angioimmunoblastic T cell lymphoma.
Schwartz FH, Cai Q, Fellmann E, Hartmann S, Mäyränpää MI, Karjalainen-Lindsberg M-L, Sundström C, Scholtysik R*, Hansmann M-L*, Küppers R*.
J. Pathol 242, 129-133, 2017. (*shared senior authors). https://doi.org/10.1002/path.4898

Concepts in mature T-cell lymphomas – highlights from an international joint symposium on T-cell immunology and oncology.
Marco Herling, Benjamin Rengstl, René Scholtysik, Sylvia Hartmann, Ralf Küppers, Martin-Leo Hansmann, Hans H. Diebner, Ingo Roeder, Hinrich Abken, Sebastian Newrzela, Jörg Kirberg.
Leukemia & Lymphoma, 58(4), 2017. https://doi.org/10.1080/10428194.2016.1222381

Tumor infiltrating HLA-matched CD4+ T cells retargeted against Hodgkin and Reed-Sternberg cells.
Rengstl B, Schmid F, Weiser C, Döring C, Heinrich T, Warner K, Becker PS, Wistinghausen R, Kameh-Var S, Werling E, Seidl C, Hartmann S, Abken H, Küppers R, Hansmann M-L, Newrzela S.
Oncoimmunol, 5, e1160186, 2016. https://doi.org/10.1080/2162402X.2016.1160186

Novel IGH and MYC translocation partners in diffuse large B cell lymphomas.
Otto C, Scholtysik R, Schmitz R, Kreuz M, Becher C, Hummel M, Rosenwald A, Trümper L, Klapper W, Siebert R, Küppers R, for the "Molecular Mechanisms in Malignant Lymphomas" network project.
Genes Chrom Cancer, 55, 932-943, 2016. https://doi.org/10.1002/gcc.22391

Finding small somatic structural variants in exome sequencing data: a machine learning approach.
Kuhn M, Stange T, Herold S, Thiede C, Roeder I
Comput. Stat. 2016. https://doi.org/10.1007/s00180-016-0674-2

CD1d-restricted peripheral T cell lymphoma in mice and humans.
Bachy E, Urb M, Chandra S, Robinot R, Bricard G, de Bernard S, Traverse-Glehen A, Gazzo S, Blond O, Khurana A, Baseggio L, Heavican T, Ffrench M, Crispatzu G, Mondière P, Schrader A, Taillardet M, Thaunat O, Martin N, Dalle S, Le Garff-Tavernier M, Salles G, Lachuer J, Hermine O, Asnafi V, Roussel M, Lamy T, Herling M, Iqbal J, Buffat L, Marche PN, Gaulard P, Kronenberg M, Defrance T, Genestier L.
J. Exp. Med. 2016 Apr 11. https://doi.org/10.1084/jem.20150794

Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance.
Spinner S, Crispatzu G, Yi JH, Munkhbaatar E, Mayer P, Höckendorf U, Müller N, Li Z, Schader T, Bendz H, Hartmann S, Yabal M, Pechloff K, Heikenwalder M, Kelly GL, Strasser A, Peschel C, Hansmann ML, Ruland J, Keller U, Newrzela S, Herling M, Jost PJ.
Leukemia. 2016 Mar 8. https://doi.org/10.1038/leu.2016.49

An evolutionary stability perspective on oncogenesis control in mature T-cell populations.
Diebner HH, Kirberg J, Roeder I.
J. Theor. Biol. 2015 Nov 5. https://doi.org/10.1016/j.jtbi.2015.10.033

Are we improving the outcome for patients with T-cell prolymphocytic leukemia by allogeneic stem cell transplantation? (editorial)
Herling M.
Eur. J. Haematol. 94, 191-2, 2015. http://dx.doi.org/10.1111/ejh.12462

Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia.
Kiel MJ, Velusamy T, Rolland D, Sahasrabuddhe AA, Chung F, Bailey NG, Schrader A, Li B, Jun Z. Li JZ, Ozel AB, Betz BL, Miranda RN, Medeiros LJ, Zhao L, Herling M, Lim MS, Elenitoba-Johnson KJS.
Blood 124, 1460-72, 2014. https://doi.org/10.1182/blood-2014-03-559542

Vitamin D controls apoptosis and proliferation of cutaneous T cell lymphoma cells. (letter)
Mrotzek C, Felcht M, Sommer A, Schrader A, Klemke CD, Herling M, Schlaak M, Fabri M.
Exp. Dermatol. 24, 798-800, 2015. https://doi.org/10.1111/exd.12746

A novel immunohistochemical classifier to distinguish Hodgkin lymphoma from ALK anaplastic large cell lymphoma.
Döring C, Hansmann ML, Agostinelli C, Piccaluga PP, Facchetti F, Pileri S, Küppers R, Newrzela S, Hartmann S.
Mod. Pathol. 2014 Mar 14. https://doi.org/10.1038/modpathol.2014.44

Mathematical modeling of oncogenesis control in mature T-cell populations.
Gerdes S, Newrzela S, Glauche I, von Laer D, Hansmann M-L, Roeder I.
Frontiers in Immunology 2013 Nov 21. https://doi.org/10.3389/fimmu.2013.00380

T-cell receptor signaling in peripheral T-cell lymphoma - a review of patterns of alterations in a central growth regulatory pathway.
Warner K, Weit N, Crispatzu G, Admirand J, Jones D, Herling M.
Curr. Hematol. Malig. Rep. 2013 Sep 8. https://doi.org/10.1007/s11899-013-0165-2

Models for mature T-cell lymphomas - A critical appraisal of experimental systems and their contribution to current T-cell tumorigenic concepts.
Warner K, Crispatzu G, Al-Ghaili N, Weit N, Florou V, You MJ, Newrzela S, Herling M.
Crit. Rev. Oncol. Hematol. 2013 Aug 20. http://dx.doi.org/10.1016/j.critrevonc.2013.07.014