CONTROL-T: International Conference April 2016

Mature T-cell lymphomas - molecular pathology, modeling of cellular dynamics, and therapeutic approaches

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Fr, 1st of April 2016
11:00-11:10 Welcome Address Prof. Bernd Brüne (Dean of Preclinic)
11:10-11:30 Welcome Address Prof. Martin-Leo Hansmann (Speaker of the Consortium)
11:30-13:00 "Session A: Challenges in T-cell tumor diagnostics
Chair: Philippe Gaulard, Martin-Leo Hansmann"

11:30-11:55 Heterogeneity of peripheral T-cell lymphomas: where do we stand?, Philippe Gaulard
11:55-12:20 Diagnosis and management of mature T cell leukaemia (TPLL and TLGL), Claire Dearden
12:20-12:45 Integrative approaches of genomic and drug profiling in mature T cell leukemias, Satu Mustjoki
12:45-13:00 Overlaps and differential diagnosis, Sylvia Hartmann
13:00-14:00 Lunch + Poster Walk
14:00-15:05 "Session B: The lesional landscape of T-cell lymphomas
Chair: Michael Hummel, Christer Sundström "

14:00-14:25 The pathogenesis of ALCL: genetic alterations, activated signaling pathways and the role of miRNAs, Falco Fend
14:25-14:50 Peripheral T-cell lymphomas in the updated WHO Classification, Stefano Pileri
14:50-15:05 Pathogenetic aspects of AITL and ALCL, Ralf Küppers
15:05-15:20 Coffee Break
15:20-16:25 "Session C: Contribution of the TCR to cellular dynamics and disease
Chair: Fritz Melchers, Jörg Kirberg"

15:20-15:45 Repertoire of pathogenic, autoreactive CD4+ T cells controlled by peripheral tolerance, Lescek Ignatowicz
15:45-16:10 Cell competition and T cell leukemia, Hans-Reimer Rodewald
16:10-16:25 Synergistic effects between TCR signaling and TCL1, Marco Herling
16:25-16:45 Coffee Break
16:45-18:15 "Session D: T-cell oncogenic mechanisms of clonal escape
Chair: Falco Fend, Marco Herling "

16:45-17:10 NPM-ALK hybrid: an ultimate oncogene of CD4+ T cells, Mariusz Wasik
17:10-17:35 Antigen Receptor Signaling in T-NHL, Jürgen Ruland
17:35-18:00 The role of mitochondrial apoptosis in peripheral T cell lymphoma survival and treatment resistance, Philipp Jost
18:00-18:15 Imaging and dynamics of NPM-ALK induced T-cell lymphoma, Sebastian Newrzela
18:15-18:30 Coffee Break
18:30-19:30 Keynote: Using DC nanovesicles for tumor immunotherapy, J. Sprent
19:30 Get together

Sat, 2nd of April 2016
8:30-9:50 "Session E: T-cell homeostasis and its in vivo and in silico modeling
Chair: Ralf Küppers, Ingo Roeder"

8:30-8:55 The erosion of the naive T cell repertoire, Rob de Boer
8:55-9:20 The repertoire of peripheral T cells is shaped by TCR signal integration in the thymus, Philippe Robert
9:20-9:35 Inequality in T cell homeostasis, Jörg Kirberg
9:35-9:50 Individual Cell-Based Mathematical Modelling of Post-Thymic TCR-(s)pMHC interactions, Hans Diebner
9:50-10:05 Coffee Break
10:05-11:20 "Session F: T-cell trafficking and interactions in the architecture of lymphoid organs
Chair: Jens Stein, Sebastian Newrzela"

10:05-10:30 Mechanisms of CD8+ T cell migration in lymphoid and non-lymphoid organs, Jens Stein
10:30-10:55 In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity, Stephan Halle
10:55-11:20 Dynamic imaging of T cells in lymph nodes and tumors, Emmanuel Donnadieu
11:20-12:30 Lunch + Poster Walk
12:30-13:40 "Session G: News from T-cell lymphoma therapy
Chair: Lorenz Trümper, Stefano Pileri
12:30-12:55 Nodal PTCL incl. Allogeneic stem cell transplantation, Lorenz Trümper
12:55-13:20 Update on Novel therapies in peripheral T-cell lymphomas, Kerry Savage
13:20-13:40 Selected Abstract: Targeting CCR7 in T-cell Prolymphocytic Leukemia, Carlos Cuesta Mateos
13:40-14:00 Coffee Break
14:00-15:50 "Session H: Applied T-cell immunology / T-cell therapy
Chair: Hinrich Abken, Wolfgang Uckert"

14:00-14:25 Mechanisms of resistance to CD19 CARs and targeting CARs to AML, Marco Ruella
14:25-14:50 In vivo transduction of T cells: The future of immunotherapy?, Wolfgang Uckert
14:50-15:15 Gene editing in T cells using TALENs, Boris Fehse
15:15-15:30 Next-generations of T-CARs, Hinrich Abken
15:30-15:50 Selected Abstract: Molecular and immunohistochemical analyses of γδ T cells infiltrating human breast carcinomas, Paul Fisch
15:50 Closing Remarks